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In this study in Shock, our group suggested that certain echocardiographic parameters may be associated with a positive response to administration of intravenous saline solutions in patients with life-threatening infection, even when patients are breathing on their own. (Prior work had been restricted to patients on the mechanical respirator, not breathing on their own.)

In this study in Cardiovascular Ultrasound Journal, our group found evidence that “mild” impairment of heart filling in patients with life-threatening infection may be associated with higher mortality. We suspect this is related to inadequate administration of intravenous salt solutions, even though older measures of adequacy (“central venous pressure”) were appropriate.