Colleagues on the ORCHID trial committee and I wrote this response to the Surgisphere hydroxychloroquine results. In the event, the papers were discovered to be based on fraudulent data, so Lancet ended up not publishing the response. However, our arguments were relevant even if the results had not been fraudulent. Given the importance of what we term “trajectory bias,” I thought it reasonable to post the paper here for future reference.
    
Samuel Brown—ICU physician, medical researcher, and cultural historian—is Associate Professor of Pulmonary and Critical Care Medicine and Medical Ethics and Humanities at Intermountain Medical Center/University of Utah and director of the Center for Humanizing Critical Care at Intermountain. Trained at Harvard College and Harvard Medical School, Dr. Brown researches and writes at the interfaces among medicine, religion, culture, and history. 
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